Unknown,Transcriptomics,Genomics,Proteomics

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Identity, proliferation capacity, genomic stability and novel senescence markers of mesenchymal stem cells isolated from low volume of human bone marrow


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Gabrielis Kundrotas 

PROVIDER: E-GEOD-68933 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identity, proliferation capacity, genomic stability and novel senescence markers of mesenchymal stem cells isolated from low volume of human bone marrow.

Kundrotas Gabrielis G   Gasperskaja Evelina E   Slapsyte Grazina G   Gudleviciene Zivile Z   Krasko Jan J   Stumbryte Ausra A   Liudkeviciene Regina R  

Oncotarget 20160301 10


Human bone marrow mesenchymal stem cells (hBM-MSCs) hold promise for treating incurable diseases and repairing of damaged tissues. However, hBM-MSCs face the disadvantages of painful invasive isolation and limited cell numbers. In this study we assessed characteristics of MSCs isolated from residual human bone marrow transplantation material and expanded to clinically relevant numbers at passages 3-4 and 6-7. Results indicated that early passage hBM-MSCs are genomically stable and retain identit  ...[more]

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