Unknown,Transcriptomics,Genomics,Proteomics

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CaArray_gray-00248: Genomic and transcriptional aberrations linked to breast cancer pathophysiologies


ABSTRACT: We measured baseline gene expression profiles for a set of breast tumors. gray-00248 Assay Type: Gene Expression Provider: Affymetrix Array Designs: U133AAofAv2 Organism: Homo sapiens (ncbitax) Tissue Sites: mammary gland Material Types: synthetic_RNA, total_RNA Disease States: breast cancer

ORGANISM(S): Homo sapiens

SUBMITTER: Mervi Heiskanen 

PROVIDER: E-GEOD-69031 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


This study explores the roles of genome copy number abnormalities (CNAs) in breast cancer pathophysiology by identifying associations between recurrent CNAs, gene expression, and clinical outcome in a set of aggressively treated early-stage breast tumors. It shows that the recurrent CNAs differ between tumor subtypes defined by expression pattern and that stratification of patients according to outcome can be improved by measuring both expression and copy number, especially high-level amplificat  ...[more]

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