Replication timing of control and siRNA PR-set7 cells
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ABSTRACT: Although histone modifications have been implicated in many DNA-dependent processes, their precise role in DNA replication remains poorly understood. Here, we show that the regulation of histone H4-K20 methylation states, in particular for the monomethylation, is a critical determinant of licensing and time activation of replication origins in mammalian cells. Two experimental condition : shRNA LUC cells (control) versus siRNA Prset-7 cells
ORGANISM(S): Homo sapiens
SUBMITTER: Jean-Charles Cadoret
PROVIDER: E-GEOD-69083 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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