Yap and Taz in Neural Crest play a Crucial Role in Smooth Muscle Development
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Min Zhang
PROVIDER: E-GEOD-69311 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Yap and Taz play a crucial role in neural crest-derived craniofacial development.
Wang Jun J Xiao Yang Y Hsu Chih-Wei CW Martinez-Traverso Idaliz M IM Zhang Min M Bai Yan Y Ishii Mamoru M Maxson Robert E RE Olson Eric N EN Dickinson Mary E ME Wythe Joshua D JD Martin James F JF
Development (Cambridge, England) 20151230 3
The role of the Hippo signaling pathway in cranial neural crest (CNC) development is poorly understood. We used the Wnt1(Cre) and Wnt1(Cre2SOR) drivers to conditionally ablate both Yap and Taz in the CNC of mice. When using either Cre driver, Yap and Taz deficiency in the CNC resulted in enlarged, hemorrhaging branchial arch blood vessels and hydrocephalus. However, Wnt1(Cre2SOR) mutants had an open cranial neural tube phenotype that was not evident in Wnt1(Cre) mutants. In O9-1 CNC cells, the l ...[more]
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Project description:We conditionally knocked out both Yap and Taz in cranial neural crest (CNC) using the Wnt1Cre driver and sequenced mRNA from embryonic day 10.5 mandibles.
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