Characterisation of the mouse megakaryocyte transcriptome
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Michael Tomlinson
PROVIDER: E-GEOD-6940 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein.
Senis Yotis A YA Tomlinson Michael G MG García Angel A Dumon Stephanie S Heath Victoria L VL Herbert John J Cobbold Stephen P SP Spalton Jennifer C JC Ayman Sinem S Antrobus Robin R Zitzmann Nicole N Bicknell Roy R Frampton Jon J Authi Kalwant S KS Martin Ashley A Wakelam Michael J O MJ Watson Stephen P SP
Molecular & cellular proteomics : MCP 20061223 3
The platelet surface is poorly characterized due to the low abundance of many membrane proteins and the lack of specialist tools for their investigation. In this study we identified novel human platelet and mouse megakaryocyte membrane proteins using specialist proteomics and genomics approaches. Three separate methods were used to enrich platelet surface proteins prior to identification by liquid chromatography and tandem mass spectrometry: lectin affinity chromatography, biotin/NeutrAvidin aff ...[more]
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