Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Expression data from fetal mouse lung from mothers fed high fibre or acetate

ABSTRACT: We used microarrays to detail the global programme of gene expression in the fetal lung late in gestation, from mothers that had been fed normal chow, high fibre, or acetate in the drinking water. The experiment was designed to examine the hypothesis that metabolites of the mother i.e. acetate could cross the placenta and influence gene transcription in the fetus. Diets used were "Normal chow" (NC) (8720310), or "High-fiber" (SF11-025) (Specialty feeds, Perth, Australia. Acetate (200 mM) was provided in the drinking water and refreshed three times per week. Gene expression in the lung may be affected by metabolites in utero. We examined whole lung of E21 fetuses from high-fiber fed mothers, normal chow fed mothers and acetate in drinking water fed mothers. Added fibre in the diet, or acetate in drinking water, would allow simple comparison with normal chow fed mothers, to determine whether fibre/acetate affected gene transcription in the fetal lung.

ORGANISM(S): Mus musculus

SUBMITTER: Charles Mackay 

PROVIDER: E-GEOD-69525 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Asthma is prevalent in Western countries, and recent explanations have evoked the actions of the gut microbiota. Here we show that feeding mice a high-fibre diet yields a distinctive gut microbiota, which increases the levels of the short-chain fatty acid, acetate. High-fibre or acetate-feeding led to marked suppression of allergic airways disease (AAD, a model for human asthma), by enhancing T-regulatory cell numbers and function. Acetate increases acetylation at the Foxp3 promoter, likely thro  ...[more]

Similar Datasets

Transcriptomics Expression data from fetal mouse lung from mothers fed high fibre or acetate
2015-06-29 | GSE69525 | GEO
Genomics Mus musculus
| PRJNA288463 | ENA
Transcriptomics Comparison of the effects upon gene expression of i.v. injection of plasma exosomes isolated from mice fed with differemt diets
2022-12-31 | GSE202854 | GEO
Transcriptomics Effect of Fumonisin B1 exposure on hepatic gene expression in mice fed a regular diet (CHOW) and in mice fed a High Fat Diet (HFD).
2023-09-01 | GSE208735 | GEO
Transcriptomics Comparison of the effects of 6 weeks high-fat diet or sucrose-supplemented drinking water upon gene expression in mice
2022-12-31 | GSE202845 | GEO
Transcriptomics In utero exposure to arsenic via drinking water impairs lung development and mucociliary clearance genes.
2013-06-04 | E-GEOD-37831 | biostudies-arrayexpress
Transcriptomics Transcription profiling of mouse lung from animals exposed to arsenic
2008-10-21 | E-GEOD-11056 | biostudies-arrayexpress
Transcriptomics Effect of six different diets on liver gene expression
2022-10-31 | GSE159090 | GEO
Transcriptomics Transcription profiling of mouse liver during regeneration
2008-06-16 | E-GEOD-9630 | biostudies-arrayexpress
Transcriptomics Expression data from mouse lung
2008-08-01 | GSE11056 | GEO