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Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis

ABSTRACT: We report the whole genome binding profile of Steroidogenic Factor 1 ChIP-seq in murine endometrium

ORGANISM(S): Mus musculus

SUBMITTER: Francesco DeMayo

PROVIDER: E-GEOD-69543 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis.

Vasquez Yasmin M YM Wu San-Pin SP Anderson Matthew L ML Hawkins Shannon M SM Creighton Chad J CJ Ray Madhumita M Tsai Sophia Y SY Tsai Ming-Jer MJ Lydon John P JP DeMayo Francesco J FJ

Molecular endocrinology (Baltimore, Md.) 20160328 5

Epigenetic silencing of steroidogenic factor 1 (SF1) is lost in endometriosis, potentially contributing to de novo local steroidogenesis favoring inflammation and growth of ectopic endometrial tissue. In this study, we examine the impact of SF1 expression in the eutopic uterus by a novel mouse model that conditionally expresses SF1 in endometrium. In vivo SF1 expression promoted the development of enlarged endometrial glands and attenuated estrogen and progesterone responsiveness. Endometriosis ...[more]

PMID: 27018534

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Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis

Project description:We report the whole genome binding profile of Steroidogenic Factor 1

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Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis.

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