Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: NATHAN HARMSTON
PROVIDER: E-GEOD-69687 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Madan B B Ke Z Z Harmston N N Ho S Y SY Frois A O AO Alam J J Jeyaraj D A DA Pendharkar V V Ghosh K K Virshup I H IH Manoharan V V Ong E H Q EH Sangthongpitag K K Hill J J Petretto E E Keller T H TH Lee M A MA Matter A A Virshup D M DM
Oncogene 20150810 17
Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part by mutations regulating the abundance of their receptors. Whether these mutations identify a clinical opportunity is an important question. Inhibition of Wnt secretion by blocking an essential post-translational modification, palmitoleation, provides a useful therapeutic intervention. We developed a novel potent, orally available PORCN inhibitor, ETC-1922159 (henceforth called ETC-159) that blocks the se ...[more]