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Transcription profiling of Integrated Stress Response induced by tunicamycin or following AP20187 induced dimerization of a Fv2E-PERK chimera in wildtype cells and cells carrying mutations in key ISR signaling molecules.

ABSTRACT: Comparison of genes induced during activation of the Integrated Stress Response by tunicamycin or following AP20187 induced dimerization of a Fv2E-PERK chimera in wildtype cells and cells carrying mutations in key ISR signaling molecules.

ORGANISM(S): Mus musculus

SUBMITTER: Heather Harding

PROVIDER: E-GEOD-700 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2.

Lu Phoebe D PD Jousse Céline C Marciniak Stefan J SJ Zhang Yuhong Y Novoa Isabel I Scheuner Donalyn D Kaufman Randal J RJ Ron David D Harding Heather P HP

The EMBO journal 20040108 1

Transient phosphorylation of the alpha-subunit of translation initiation factor 2 (eIF2alpha) represses translation and activates select gene expression under diverse stressful conditions. Defects in the eIF2alpha phosphorylation-dependent integrated stress response impair resistance to accumulation of malfolded proteins in the endoplasmic reticulum (ER stress), to oxidative stress and to nutrient deprivations. To study the hypothesized protective role of eIF2alpha phosphorylation in isolation o ...[more]

PMID: 14713949

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