Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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CaArray_jacks-00113: Murine KRASLA lung cancer gene expression


ABSTRACT: Tumors from 5-6 month old KrasLA mice were dissected. Gene expression analysis on U74A affy chips. 19 normal lungs from age matched controls were also includeed **NOTE: Migrated from caArray 1.x, identifier='gov.nih.nci.ncicb.caarray:Experiment:1015897590231167:1' jacks-00113 Assay Type: Gene Expression Provider: Affymetrix Array Designs: mg_u74av2 Organism: Mus musculus (ncbitax) Tissue Sites: Lung Material Types: synthetic_DNA, synthetic_RNA, organism_part Disease States: normal lung, lung cancer

ORGANISM(S): Mus musculus

SUBMITTER: Mervi Heiskanen 

PROVIDER: E-GEOD-70271 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Comparison of gene expression and DNA copy number changes in a murine model of lung cancer.

Sweet-Cordero Alejandro A   Tseng George C GC   You Han H   Douglass Margaret M   Huey Bing B   Albertson Donna D   Jacks Tyler T  

Genes, chromosomes & cancer 20060401 4


Activation of oncogenic Kras in murine lung leads to the development of numerous small adenomas, only some of which progress over time to overt adenocarcinoma. Thus, although Kras is the initiating oncogene, it is likely that secondary genetic events are required for progression from adenoma to adenocarcinoma. Some of these secondary events may also be important in human lung adenocarcinoma. By comparing gene expression profiles with DNA copy number changes, we sought to identify genes that play  ...[more]

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