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Transcription profiling of human peripheral blood mononuclear (PBMC) cells in pulmonary arterial hypertension

ABSTRACT: Microarray analysis of peripheral blood mononuclear (PBMC) cells in pulmonary arterial hypertension.

ORGANISM(S): Homo sapiens

DISEASE(S): pulmonary arterial hypertension

SUBMITTER: Christopher Coldren

PROVIDER: E-GEOD-703 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene microarray analysis of peripheral blood cells in pulmonary arterial hypertension.

Bull Todd M TM Coldren Christopher D CD Moore Mark M Sotto-Santiago Sylk M SM Pham David V DV Nana-Sinkam S Patrick SP Voelkel Norbert F NF Geraci Mark W MW

American journal of respiratory and critical care medicine 20040623 8

The importance of genetic predisposition, inflammation, and autoimmune mechanisms in the development of pulmonary arterial hypertension (PAH) is becoming increasingly clear. We hypothesized that the analysis of gene expression profiles from peripheral blood mononuclear cells would distinguish patients with PAH from normal volunteers. We also hypothesized that a subset of genes would discriminate between patients with idiopathic PAH and pulmonary hypertension related to secondary causes. Mononucl ...[more]

PMID: 15215156

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