Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Reconstruction of microRNA/genes transcriptional regulatory networks of multiple myeloma through in silico integrative genomics analysis


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Luca Agnelli 

PROVIDER: E-GEOD-70323 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Disentangling the microRNA regulatory milieu in multiple myeloma: integrative genomics analysis outlines mixed miRNA-TF circuits and pathway-derived networks modulated in t(4;14) patients.

Calura Enrica E   Bisognin Andrea A   Manzoni Martina M   Todoerti Katia K   Taiana Elisa E   Sales Gabriele G   Morgan Gareth J GJ   Tonon Giovanni G   Amodio Nicola N   Tassone Pierfrancesco P   Neri Antonino A   Agnelli Luca L   Romualdi Chiara C   Bortoluzzi Stefania S  

Oncotarget 20160101 3


The identification of overexpressed miRNAs in multiple myeloma (MM) has progressively added a further level of complexity to MM biology. miRNA and gene expression profiles of two large representative MM datasets, available from retrospective and prospective series and encompassing a total of 249 patients at diagnosis, were analyzed by means of in silico integrative genomics methods, based on MAGIA2 and Micrographite computational procedures. We first identified relevant miRNA/transcription facto  ...[more]

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