Tbx15 Controls Skeletal Muscle Fiber Type Determination and Muscle Metabolism

ABSTRACT: Skeletal muscle is composed of both slow-twich oxidative myofibers and fast-twitch glycolytic myofibers that differentially impact muscle metabolism, function, and eventually whole-body physiology. In the present study, we find that the mesodermal transcription factor T-box 15 (Tbx15) is highly and specifically expressed in glycolytic myofibers. Ablation of Tbx15 in vivo leads to a decrease in muscle size due to a decrease in the number of glycolytic fibers, associated with a small increase in the number of oxidative fibers. This shift in fiber composition results in muscles with slower myofiber contraction and relaxation, and also results in decreased whole-body oxygen consumption, decreased spontaneous activity, increased adiposity, and glucose intolerance. In order to identify genes reg

ORGANISM(S): Mus musculus

SUBMITTER: Kevin Lee 

PROVIDER: E-GEOD-70489 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress