Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Alexandros Tzatsos
PROVIDER: E-GEOD-70728 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
The Journal of clinical investigation 20160125 3
The development of the hematopoietic system is a dynamic process that is controlled by the interplay between transcriptional and epigenetic networks to determine cellular identity. These networks are critical for lineage specification and are frequently dysregulated in leukemias. Here, we identified histone demethylase KDM2B as a critical regulator of definitive hematopoiesis and lineage commitment of murine hematopoietic stem and progenitor cells (HSPCs). RNA sequencing of Kdm2b-null HSPCs and ...[more]