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Genome-wide analysis of the isogenic embryonic and induced pluripotent stem cell lines revealed no traces of parental cell type or reprogramming process and provided the approach for the best clone selection [gene expression]

ABSTRACT: Genome-wide analysis of two parental human embryonic stem cell (ESC) lines (hESM01 and n5), three n5-derived somatic cell lines (N-neurons, F-fibroblasts, R-retinal pigment epithelium), and three pairs of induced pluripotent stem cell (iPSC) clones (iN, iF, iR) at gene expression level. All lines are isogenic. In the present study an accuracy of reprogramming was tested and a universal signature of iPSCs was found. Total RNA obtained from isogenic cell lines compared to each other. For each line there are a biological (different passages) or technical (same passage) replicate.

ORGANISM(S): Homo sapiens

SUBMITTER: Maria Shutova

PROVIDER: E-GEOD-70735 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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