Unknown,Transcriptomics,Genomics,Proteomics

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Systematic Identification of Factors Crucial for Provirus Silencing in Embryonic Stem Cells (RNA-seq)


ABSTRACT: Our study reports the first genome-wide atlas of functional nodes that mediate proviral silencing in ESCs. It provides evidences for the comprehensive, interconnected and multi-layered genetic/epigenetic machineries by which ESCs maintain the repressive state of provirus and ERVs. RNA-seq analysis to determine the regulated endogenous retroviruses by Histone chaperones (Chaf1a/b), sumoylation factors (Sumo2/ Ube2i/Sae1/Uba2/Senp6) and chromatin modifiers (Trim28/Eset/Atf7ip)

ORGANISM(S): Mus musculus

SUBMITTER: Chadi EL Farran 

PROVIDER: E-GEOD-70863 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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