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Fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation [Rn]

ABSTRACT: Determination of the mechanism by which fibrinogen, a central blood coagulation protein drives immunological responses targeted to the CNS. Results identify the factors involved in the regulation and provide mechanistic basis. We subjected fibrin-stimulated microglia to microarray to determine the genes involved in innate and adaptive immune responses by fibrinogen deposited in the CNS after blood-brain barrier disruption. Rat microglia were stimulated with fibrin for 6 hr and subjected for RNA extraction and hybridization on Affymatrix microarrays. Two unstimulated and two fibrin-stimulated samples were generated.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Katerina Akassoglou

PROVIDER: E-GEOD-71083 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation [Rn]

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