Unknown,Transcriptomics,Genomics,Proteomics

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ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory (ChIP)


ABSTRACT: Immunological memory is generally thought to be mediated exclusively by lymphocytes such as memory T and B cells. However, enhanced innate immune responses caused by a previous infection increase protection against reinfection suggesting the presence of innate immunological memory. Here, we describe 3,811 ATF7 binding sites in mouse peritoneal macrophages, and 95% of the ATF7 signals in wild-type macrophages are lost in ATF7 knockout macrophages. ATF7 suppresses a group of innate-immunity genes in macrophage by recruiting H3K9 dimethyltransferase G9a. TLR ligands induce ATF7 phosphorylation, leading to release of ATF7 from chromatin and reduction in H3K9me2 level. Partially disrupted chromatin structure and increased basal expression on target genes are maintained for a long period, increasing resistance pathogens. Therefore we speculate ATF7 is important factor in controlling innate immunological memory. This series contains one set of whole genome ChIP-chip data and 2 sets of promoter array ChIP-chip data. For all sample, we use three IP .CEL files and three WCE .CEL files (they are triplicated experiments) to make one profile.

ORGANISM(S): Mus musculus

SUBMITTER: Keisuke Yoshida 

PROVIDER: E-GEOD-71112 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory.

Yoshida Keisuke K   Maekawa Toshio T   Zhu Yujuan Y   Renard-Guillet Claire C   Chatton Bruno B   Inoue Kentaro K   Uchiyama Takeru T   Ishibashi Ken-ichi K   Yamada Takuji T   Ohno Naohito N   Shirahige Katsuhiko K   Okada-Hatakeyama Mariko M   Ishii Shunsuke S  

Nature immunology 20150831 10


Immunological memory is thought to be mediated exclusively by lymphocytes. However, enhanced innate immune responses caused by a previous infection increase protection against reinfection, which suggests the presence of innate immunological memory. Here we identified an important role for the stress-response transcription factor ATF7 in innate immunological memory. ATF7 suppressed a group of genes encoding factors involved in innate immunity in macrophages by recruiting the histone H3K9 dimethyl  ...[more]

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