Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Johannes Beckers
PROVIDER: E-GEOD-7119 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Bach Christian C Gilch Sabine S Rost Romina R Greenwood Alex D AD Horsch Marion M Hajj Glaucia N M GN Brodesser Susanne S Facius Axel A Schädler Sandra S Sandhoff Konrad K Beckers Johannes J Leib-Mösch Christine C Schätzl Hermann M HM Vorberg Ina I
The Journal of biological chemistry 20090911 45
Prion diseases are neurodegenerative diseases associated with the accumulation of a pathogenic isoform of the host-encoded prion protein. The cellular responses to prion infection are not well defined. By performing microarray analysis on cultured neuronal cells infected with prion strain 22L, in the group of up-regulated genes we observed predominantly genes of the cholesterol pathway. Increased transcript levels of at least nine enzymes involved in cholesterol synthesis, including the gene for ...[more]