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Identification of genes associated with breast cancer micrometastatic disease in bone marrow disseminated tumor cells (DTCs)

ABSTRACT: In this study, we assess the effect of zoledronic acid on clearance of disseminated tumour cells (DTCs) from the bone marrow in women undergoing neoadjuvant chemotherapy for breast cancer In this dataset, Primary breast tissue from stage II or III breast cancer patients were included in the analysis. This study allowed the identification of novel gene expression patterns associated with the presence of DTCs BM by IHC and supports the concept of epithelial to mesenchymal transition transition (EMT) of DTCs present in the BM .

ORGANISM(S): Homo sapiens

SUBMITTER: chidananda Mudalagiriyappa

PROVIDER: E-GEOD-71258 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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CXCR4 Protein Epitope Mimetic Antagonist POL5551 Disrupts Metastasis and Enhances Chemotherapy Effect in Triple-Negative Breast Cancer.

Xiang Jingyu J Hurchla Michelle A MA Fontana Francesca F Su Xinming X Amend Sarah R SR Esser Alison K AK Douglas Garry J GJ Mudalagiriyappa Chidananda C Luker Kathryn E KE Pluard Timothy T Ademuyiwa Foluso O FO Romagnoli Barbara B Tuffin Gérald G Chevalier Eric E Luker Gary D GD Bauer Michael M Zimmermann Johann J Aft Rebecca L RL Dembowsky Klaus K Weilbaecher Katherine N KN

Molecular cancer therapeutics 20150812 11

The SDF-1 receptor CXCR4 has been associated with early metastasis and poorer prognosis in breast cancers, especially the most aggressive triple-negative subtype. In line with previous reports, we found that tumoral CXCR4 expression in patients with locally advanced breast cancer was associated with increased metastases and rapid tumor progression. Moreover, high CXCR4 expression identified a group of bone marrow-disseminated tumor cells (DTC)-negative patients at high risk for metastasis and de ...[more]

PMID: 26269605

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