Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jeff Blackinton
PROVIDER: E-GEOD-71382 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Blackinton Jeff G JG Keene Jack D JD
Nucleic acids research 20151020 1
Global mRNA abundance depends on the balance of synthesis and decay of a population of mRNAs. To account for this balance during activation of T cells, we used metabolic labeling to quantify the contributions of RNA transcription and decay over a 4 h time course during activation of leukemia-derived Jurkat T cells. While prior studies suggested more than half of the changes in mRNA abundance were due to RNA stability, we found a smaller but more interesting population of mRNAs changed stability. ...[more]