Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Hemang Parikh
PROVIDER: E-GEOD-7146 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Parikh Hemang H Carlsson Emma E Chutkow William A WA Johansson Lovisa E LE Storgaard Heidi H Poulsen Pernille P Saxena Richa R Ladd Christine C Schulze P Christian PC Mazzini Michael J MJ Jensen Christine Bjørn CB Krook Anna A Björnholm Marie M Tornqvist Hans H Zierath Juleen R JR Ridderstråle Martin M Altshuler David D Lee Richard T RT Vaag Allan A Groop Leif C LC Mootha Vamsi K VK
PLoS medicine 20070501 5
<h4>Background</h4>Type 2 diabetes mellitus (T2DM) is characterized by defects in insulin secretion and action. Impaired glucose uptake in skeletal muscle is believed to be one of the earliest features in the natural history of T2DM, although underlying mechanisms remain obscure.<h4>Methods and findings</h4>We combined human insulin/glucose clamp physiological studies with genome-wide expression profiling to identify thioredoxin interacting protein (TXNIP) as a gene whose expression is powerfull ...[more]