Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of human Melanoma cell lines to investigate differences in wild-type p14ARF and mutant 14ARF

ABSTRACT: 35 Melanoma cell lines hybridized to Affymetrix Hu133_Plus 2 microarrays were analysed for genes differentially expressed between cell lines carrying wild-type p14ARF and those with mutant 14ARF. All of these cell lines contained wild-type p53 (so that the effects of p14ARF mutations could be analysed without contamination from p53). Experiment Overall Design: The aim of this study was to identify downstream effectors of p14ARF in melanoma. Relevant paper: Packer et al. (2007) Int J Cancer.

ORGANISM(S): Homo sapiens

SUBMITTER: Leisl Packer

PROVIDER: E-GEOD-7152 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression profiling in melanoma identifies novel downstream effectors of p14ARF.

Packer Leisl M LM Pavey Sandra J SJ Boyle Glen M GM Stark Mitchell S MS Ayub Ana L AL Rizos Helen H Hayward Nicholas K NK

International journal of cancer 20070801 4

p14ARF is inactivated by deletions/mutations in many cancer types and can suppress cell growth by both p53-dependent and p53-independent mechanisms. To identify novel downstream effectors of p14ARF, we used gene expression profiling as a primary screening tool to select candidates for follow up validation studies using in vitro cell-based assays. Gene expression profiles of a panel of 35 melanoma cell lines with either wild-type (n = 12) or mutant (n = 23) p14ARF were compared to identify genes ...[more]

PMID: 17450523

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Dataset Information

Transcription profiling of human Melanoma cell lines to investigate differences in wild-type p14ARF and mutant 14ARF

Publications

Gene expression profiling in melanoma identifies novel downstream effectors of p14ARF.

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