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Identification of global regulators of T-helper cell lineage specification (RNA-Seq)

ABSTRACT: The aim of the dataset was to identify genome-wide regulators of gene expression in early differentiation of human cord blood derived CD4+ T cells cultured under Th1 (Act+IL12) and Th2 (Act+IL4) polarizing conditions. Total RNA from naive CD4+ T cells was compared to total RNA from cells cultured in the following three conditions: activating (antiCD3+antiCD28)+antiIL4+antiIFNG; activating (antiCD3+antiCD28)+IL12+antiIL4; activating (antiCD3+antiCD28) +IL4+antiIFNG. Samples from 3 biological replicates were analysed.

ORGANISM(S): Homo sapiens

SUBMITTER: Kartiek Kanduri 

PROVIDER: E-GEOD-71645 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of global regulators of T-helper cell lineage specification.

Kanduri Kartiek K   Tripathi Subhash S   Larjo Antti A   Mannerström Henrik H   Ullah Ubaid U   Lund Riikka R   Hawkins R David RD   Ren Bing B   Lähdesmäki Harri H   Lahesmaa Riitta R  

Genome medicine 20151120

<h4>Background</h4>Activation and differentiation of T-helper (Th) cells into Th1 and Th2 types is a complex process orchestrated by distinct gene activation programs engaging a number of genes. This process is crucial for a robust immune response and an imbalance might lead to disease states such as autoimmune diseases or allergy. Therefore, identification of genes involved in this process is paramount to further understand the pathogenesis of, and design interventions for, immune-mediated dise  ...[more]

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