Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Magalie Celton
PROVIDER: E-GEOD-71686 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Barabé F F Gil L L Celton M M Bergeron A A Lamontagne V V Roques É É Lagacé K K Forest A A Johnson R R Pécheux L L Simard J J Pelloux J J Bellemare-Pelletier A A Gagnon E E Hébert J J Cellot S S Wilhelm B T BT
Leukemia 20161026 5
Acute myeloid leukemias (AMLs) result from a series of genetic events occurring in a stem or progenitor hematopoietic cell that gives rise to their clonal expansion and an impaired capacity to differentiate. To circumvent the genetic heterogeneity of AML patient cohorts, we have developed a model system, driven by the MLL-AF9 (MA9) oncogene, to generate multiple human leukemias using progenitor cells from a single healthy donor. Through stepwise RNA-sequencing data generated using this model and ...[more]