Transcriptional profiling of inducible GATA6L-overexpressing HT-29 cells stimulated with TNF
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Kevin Janes
PROVIDER: E-GEOD-72079 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors.
Chitforoushzadeh Zeinab Z Ye Zi Z Sheng Ziran Z LaRue Silvia S Fry Rebecca C RC Lauffenburger Douglas A DA Janes Kevin A KA
Science signaling 20160607 431
Signal transduction networks coordinate transcriptional programs activated by diverse extracellular stimuli, such as growth factors and cytokines. Cells receive multiple stimuli simultaneously, and mapping how activation of the integrated signaling network affects gene expression is a challenge. We stimulated colon adenocarcinoma cells with various combinations of the cytokine tumor necrosis factor (TNF) and the growth factors insulin and epidermal growth factor (EGF) to investigate signal integ ...[more]
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