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Transcription profiling of mouse B cells expressing anti-HEL IgM BCR and IgMG BCR to investigate the effect of IgG cytoplasmic tail on BCR-respose genes

ABSTRACT: IgG cytoplasmic tail interferes with the induction of antigen-response genes Experiment Overall Design: Comparing antigen-induced genes between B cells expressing anti-HEL IgM BCR and IgMG BCR (chimeric receptor where the extracellular spacer, transmembrane, and cytoplasmic domain of IgM are replaced with those of IgG1)

ORGANISM(S): Mus musculus

SUBMITTER: Keisuke Horikawa

PROVIDER: E-GEOD-7218 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors.

Horikawa Keisuke K Martin Stephen W SW Pogue Sarah L SL Silver Karlee K Peng Kaiman K Takatsu Kiyoshi K Goodnow Christopher C CC

The Journal of experimental medicine 20070409 4

Immunological memory is characterized by heightened immunoglobulin (Ig) G antibody production caused in part by enhanced plasma cell formation conferred by conserved transmembrane and cytoplasmic segments in isotype-switched IgG B cell receptors. We tested the hypothesis that the IgG tail enhances intracellular B cell antigen receptor (BCR) signaling responses to antigen by analyzing B cells from Ig transgenic mice with IgM receptors or chimeric IgMG receptors containing the IgG tail segment. Th ...[more]

PMID: 17420266

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