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Expression profile of PBMCs following decitabine treatment

ABSTRACT: The epigenetic regulation, for example, DNA methylation, controls the development and differentiation of both tumor cells and immunocytes. Treatment with DNA demethylating agent (such as decitabine) has shown a dramatic clinical benefit in hematological malignancies and solid tumors. However, the influence of epigenetic therapy on host immune system remains unclear. To investigate the effects of low-dose decitabine therapy on T cells, We collected whole blood samples from two solid tumor patients pre and post low-dose decitabine therapy, and detected the expression profiles of PBMCs.

ORGANISM(S): Homo sapiens

SUBMITTER: Jing Nie

PROVIDER: E-GEOD-72686 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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