Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Christina Yau
PROVIDER: E-GEOD-72977 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Yau Christina C Meyer Laurence L Benz Stephen S Vaske Charles C Scott Gary G Egan Brian B Labhart Paul P Pourmand Nader N Benz Christopher C CC
Breast cancer research and treatment 20151012 1
FOXM1 is a key transcription factor regulating cell cycle progression, DNA damage response, and a host of other hallmark cancer features, but the role of the FOXM1 cistrome in driving estrogen receptor-positive (ER+) versus estrogen receptor-negative (ER-) breast cancer clinical outcomes remains undefined. Chromatin immunoprecipitation sequencing (ChIP-Seq) coupled with RNA sequencing (RNA-Seq) analyses was used to identify FOXM1 target genes in breast cancer cells (MCF-7) where FOXM1 expression ...[more]