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Transcription profiling of human lymphoblastoid cells from individuals with autism and duplication of 15q11-13autism with dup(15q)

ABSTRACT: gene expression profiles of lymphoblastoid cells from individuals with autism and duplication of 15q11-13 Experiment Overall Design: Cy5; each male with autism and dup(15q) Experiment Overall Design: Cy3; pool of 14 unrelated individuals.

ORGANISM(S): Homo sapiens

SUBMITTER: Yuhei Nishimura

PROVIDER: E-GEOD-7315 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways.

Nishimura Yuhei Y Martin Christa L CL Vazquez-Lopez Araceli A Spence Sarah J SJ Alvarez-Retuerto Ana Isabel AI Sigman Marian M Steindler Corinna C Pellegrini Sandra S Schanen N Carolyn NC Warren Stephen T ST Geschwind Daniel H DH

Human molecular genetics 20070521 14

Autism is a heterogeneous condition that is likely to result from the combined effects of multiple genetic factors interacting with environmental factors. Given its complexity, the study of autism associated with Mendelian single gene disorders or known chromosomal etiologies provides an important perspective. We used microarray analysis to compare the mRNA expression profile in lymphoblastoid cells from males with autism due to a fragile X mutation (FMR1-FM), or a 15q11-q13 duplication (dup(15q ...[more]

PMID: 17519220

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