Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Chad Creighton
PROVIDER: E-GEOD-7327 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Massarweh Suleiman S Osborne C Kent CK Creighton Chad J CJ Qin Lanfang L Tsimelzon Anna A Huang Shixia S Weiss Heidi H Rimawi Mothaffar M Schiff Rachel R
Cancer research 20080201 3
Not all breast cancers respond to tamoxifen, and many develop resistance despite initial benefit. We used an in vivo model of estrogen receptor (ER)-positive breast cancer (MCF-7 xenografts) to investigate mechanisms of this resistance and develop strategies to circumvent it. Epidermal growth factor receptor (EGFR) and HER2, which were barely detected in control estrogen-treated tumors, increased slightly with tamoxifen and were markedly increased when tumors became resistant. Gefitinib, which i ...[more]