Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Kate Meyer
PROVIDER: E-GEOD-73405 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Meyer Kate D KD Patil Deepak P DP Zhou Jun J Zinoviev Alexandra A Skabkin Maxim A MA Elemento Olivier O Pestova Tatyana V TV Qian Shu-Bing SB Jaffrey Samie R SR
Cell 20151022 4
Protein translation typically begins with the recruitment of the 43S ribosomal complex to the 5' cap of mRNAs by a cap-binding complex. However, some transcripts are translated in a cap-independent manner through poorly understood mechanisms. Here, we show that mRNAs containing N(6)-methyladenosine (m(6)A) in their 5' UTR can be translated in a cap-independent manner. A single 5' UTR m(6)A directly binds eukaryotic initiation factor 3 (eIF3), which is sufficient to recruit the 43S complex to ini ...[more]