Divergent residues within histone H3 define a unique chromatin structure in S. cerevisiae
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Benjamin Martin
PROVIDER: E-GEOD-73425 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Divergent Residues Within Histone H3 Dictate a Unique Chromatin Structure in Saccharomyces cerevisiae.
McBurney Kristina L KL Leung Andrew A Choi Jennifer K JK Martin Benjamin J E BJ Irwin Nicholas A T NA Bartke Till T Nelson Christopher J CJ Howe LeAnn J LJ
Genetics 20151103 1
Histones are among the most conserved proteins known, but organismal differences do exist. In this study, we examined the contribution that divergent amino acids within histone H3 make to cell growth and chromatin structure in Saccharomyces cerevisiae. We show that, while amino acids that define histone H3.3 are dispensable for yeast growth, substitution of residues within the histone H3 α3 helix with human counterparts results in a severe growth defect. Mutations within this domain also result ...[more]
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