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CaSR modulator in neuroblastoma model

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Carmen de Torres

PROVIDER: E-GEOD-73509 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cinacalcet inhibits neuroblastoma tumor growth and upregulates cancer-testis antigens.

Rodríguez-Hernández Carlos J CJ Mateo-Lozano Silvia S García Marta M Casalà Carla C Briansó Ferran F Castrejón Nerea N Rodríguez Eva E Suñol Mariona M Carcaboso Angel M AM Lavarino Cinzia C Mora Jaume J de Torres Carmen C

Oncotarget 20160301 13

The calcium-sensing receptor is a G protein-coupled receptor that exerts cell-type specific functions in numerous tissues and some cancers. We have previously reported that this receptor exhibits tumor suppressor properties in neuroblastoma. We have now assessed cinacalcet, an allosteric activator of the CaSR approved for clinical use, as targeted therapy for this developmental tumor using neuroblastoma cell lines and patient-derived xenografts (PDX) with different MYCN and TP53 status. In vitro ...[more]

PMID: 26893368

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