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Primary neuroblastoma tumors

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Maral Saadati

PROVIDER: E-GEOD-73518 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrative Genome-Scale Analysis Identifies Epigenetic Mechanisms of Transcriptional Deregulation in Unfavorable Neuroblastomas.

Henrich Kai-Oliver KO Bender Sebastian S Saadati Maral M Dreidax Daniel D Gartlgruber Moritz M Shao Chunxuan C Herrmann Carl C Wiesenfarth Manuel M Parzonka Martha M Wehrmann Lea L Fischer Matthias M Duffy David J DJ Bell Emma E Torkov Alica A Schmezer Peter P Plass Christoph C Höfer Thomas T Benner Axel A Pfister Stefan M SM Westermann Frank F

Cancer research 20160907 18

The broad clinical spectrum of neuroblastoma ranges from spontaneous regression to rapid progression despite intensive multimodal therapy. This diversity is not fully explained by known genetic aberrations, suggesting the possibility of epigenetic involvement in pathogenesis. In pursuit of this hypothesis, we took an integrative approach to analyze the methylomes, transcriptomes, and copy number variations in 105 cases of neuroblastoma, complemented by primary tumor- and cell line-derived global ...[more]

PMID: 27635046

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DNA methylation data from primary neuroblastoma tumors

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2016-09-08 | E-GEOD-73515 | biostudies-arrayexpress

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Project description:We performed integrative methylation, gene dosage and expression profiling to explore the interplay between promoter methylation and loss in gene silencing at 3p11-p14 in cervical cancer. Totally 26 hypermethylated genes were identified by comparing the methylation level of individual CpG sites with corresponding data of normal cervical tissue. Candidate methylation regulated genes in tumors were proposed from the correlation between methylation and gene expression. Integrated analysis of methylation, gene dosage and expression revealed three significant regulation patterns encompassing 8 hypermethylated genes; a methylation driven pattern, a gene dosage driven pattern, and a combined methylation and gene dosage driven pattern. For the LRIG1 gene, patients with both hypermethylation and loss had a worse outcome compared to those harboring only hypermethylation or none of the events. C3orf14 emerged as a novel methylation regulated suppressor gene, for which knockdown was found to promote invasive growth in human papilloma virus (HPV)-transformed keratinocytes. Methylation levels from Illumina 450K methylation arrays were correlated with Illumina gene expression data in cohort 1 and validated in cohort 2.

2015-09-14 | E-GEOD-68339 | biostudies-arrayexpress

Epigenetic profiling in CD4 and CD8 T cells from Gravesâ disease patients reveals changes in genes associated with T cell receptor signaling [methylation]

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2016-08-11 | E-GEOD-71523 | biostudies-arrayexpress

Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis

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Epigenetic profiling in CD4 and CD8 T cells from Graves disease patients reveals changes in genes associated with T cell receptor signaling

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-11-06 | E-GEOD-71957 | biostudies-arrayexpress

Integrative analysis of methylome and transcriptome in human blood identifies extensive sex and immune cell-specific differentially methylated regions

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-07-01 | E-GEOD-71245 | biostudies-arrayexpress

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