Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Shamit Soneji
PROVIDER: E-GEOD-73641 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Billing Matilda M Rörby Emma E May Gillian G Tipping Alex J AJ Soneji Shamit S Brown John J Salminen Marjo M Karlsson Göran G Enver Tariq T Karlsson Stefan S
Experimental hematology 20160210 5
Transforming growth factor β (TGFβ) is a potent inhibitor of hematopoietic stem and progenitor cell proliferation. However, the precise mechanism for this effect is unknown. Here, we have identified the transcription factor Gata2, previously described as an important regulator of hematopoietic stem cell function, as an early and direct target gene for TGFβ-induced Smad signaling in hematopoietic progenitor cells. We also report that Gata2 is involved in mediating a significant part of the TGFβ r ...[more]