Identification of protein-coding and intronic noncoding RNAs down-regulated in clear cell renal carcinoma

ABSTRACT: The clear cell subtype of renal cell carcinoma (RCC) is the most lethal and prevalent cancer of the urinary system. To investigate the molecular changes associated with malignant transformation in clear cell RCC, the gene expression profiles of matched samples of tumor and adjacent non-neoplastic tissue were obtained from 6 patients. A custom-built cDNA microarray platform was used, comprising 2,292 probes that map to exons of genes and 822 probes for noncoding RNAs mapping to intronic regions. Intronic transcription was detected in all normal and neoplastic renal tissues. A subset of 55 transcripts was significantly down-regulated in clear cell RCC relative to the matched non-tumor tissue as determined by a combination of two statistical tests and leave-one-out patient cross-validation. A

ORGANISM(S): Homo sapiens

SUBMITTER: Giselle Vignal 

PROVIDER: E-GEOD-7367 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress