Gene expression profiling of mouse luminal uterine epithelium with knockout of ALK3
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Chad Creighton
PROVIDER: E-GEOD-73717 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Uterine ALK3 is essential during the window of implantation.
Monsivais Diana D Clementi Caterina C Peng Jia J Titus Mary M MM Barrish James P JP Creighton Chad J CJ Lydon John P JP DeMayo Francesco J FJ Matzuk Martin M MM
Proceedings of the National Academy of Sciences of the United States of America 20151231 3
The window of implantation is defined by the inhibition of uterine epithelial proliferation, structural epithelial cell remodeling, and attenuated estrogen (E2) response. These changes occur via paracrine signaling between the uterine epithelium and stroma. Because implantation defects are a major cause of infertility in women, identifying these signaling pathways will improve infertility interventions. Bone morphogenetic proteins (BMPs) are TGF-β family members that regulate the postimplantatio ...[more]
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