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Whole Blood long non-coding RNA and mRNA Expression Profiles in Humans Exposed to Multi-walled Carbon Nanotubes

ABSTRACT: As the application of carbon nanotubes (CNT) in consumer products continues to rise, studies have expanded to determine the associated risks of exposure on human and environmental health. In particular, several lines of evidence indicate that exposure to multi-walled carbon nanotubes (MWCNT) could pose a carcinogenic risk similar to asbestos fibers. However, to date the potential markers of MWCNT exposure are not yet explored in humans. Global mRNA and lncRNA expression profiles in the whole blood of exposed workers, having direct contact with MWCNT aerosols for atleast 6 months (n=8), were compared with expression profiles of non-exposed (n=7) workers (e.g., proffessional and/or technical staff) from the same manufacturing facility.

ORGANISM(S): Homo sapiens

SUBMITTER: Anna Shvedova

PROVIDER: E-GEOD-73830 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrated Analysis of Dysregulated ncRNA and mRNA Expression Profiles in Humans Exposed to Carbon Nanotubes.

Shvedova Anna A AA Yanamala Naveena N Kisin Elena R ER Khailullin Timur O TO Birch M Eileen ME Fatkhutdinova Liliya M LM

PloS one 20160301 3

<h4>Background</h4>As the application of carbon nanotubes (CNT) in consumer products continues to rise, studies have expanded to determine the associated risks of exposure on human and environmental health. In particular, several lines of evidence indicate that exposure to multi-walled carbon nanotubes (MWCNT) could pose a carcinogenic risk similar to asbestos fibers. However, to date the potential markers of MWCNT exposure are not yet explored in humans.<h4>Methods</h4>In the present study, glo ...[more]

PMID: 26930275

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