Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Edwin Ostrin
PROVIDER: E-GEOD-73861 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Yang Jun J Hernandez Belinda J BJ Martinez Alanis Denise D Narvaez del Pilar Odemaris O Vila-Ellis Lisandra L Akiyama Haruhiko H Evans Scott E SE Ostrin Edwin J EJ Chen Jichao J
Development (Cambridge, England) 20151119 1
Alveolar type 1 (AT1) cells cover >95% of the gas exchange surface and are extremely thin to facilitate passive gas diffusion. The development of these highly specialized cells and its coordination with the formation of the honeycomb-like alveolar structure are poorly understood. Using new marker-based stereology and single-cell imaging methods, we show that AT1 cells in the mouse lung form expansive thin cellular extensions via a non-proliferative two-step process while retaining cellular plast ...[more]