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Gene profile analysis of sorted Sca1+/cKit- BMCs obtained from young and aged mice bearing tumor or not

ABSTRACT: Sca1+/cKit– hematopoietic BMCs of hosts bearing primary tumors promote the growth of distant tumors that form with a myofibroblast-rich, desmoplastic stroma. BMCs from old mice bearing primary tumors lack this ability Sca1+/cKit- BMCs were isolated from young and old mice bearing Matrigel control or size-matched primary tumors by FACS directly into RLT Plus Buffer (Qiagen Rneasy Plus Micro Kit)

ORGANISM(S): Mus musculus

SUBMITTER: Andreas Sjödin 

PROVIDER: E-GEOD-74120 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Hematopoietic Age at Onset of Triple-Negative Breast Cancer Dictates Disease Aggressiveness and Progression.

Marsh Timothy T   Wong Irene I   Sceneay Jaclyn J   Barakat Amey A   Qin Yuanbo Y   Sjödin Andreas A   Alspach Elise E   Nilsson Björn B   Stewart Sheila A SA   McAllister Sandra S SS  

Cancer research 20160407 10

Triple-negative breast cancer (TNBC) is considered an early onset subtype of breast cancer that carries with it a poorer prognosis in young rather than older women for reasons that remain poorly understood. Hematopoiesis in the bone marrow becomes altered with age and may therefore affect the composition of tumor-infiltrating hematopoietic cells and subsequent tumor progression. In this study, we investigated how age- and tumor-dependent changes to bone marrow-derived hematopoietic cells impact  ...[more]

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