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Transcription profiling of Escherichia coli strain 8624 and Escherichia coli strain VS94 grown with various signaling molecules

ABSTRACT: These E. coli strains were grown with various signaling molecules and the expression profiles were determined. Experiment Overall Design: These E. coli strains were grown with various signaling molecules and the expression profiles were determined using the Affymetrix E. coli 2.0 Array. Experiment Overall Design: Comparisons of the profiles were used to guide further examination using RT-PCR.

ORGANISM(S): Escherichia coli

SUBMITTER: David Rasko

PROVIDER: E-GEOD-7439 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Global effects of the cell-to-cell signaling molecules autoinducer-2, autoinducer-3, and epinephrine in a luxS mutant of enterohemorrhagic Escherichia coli.

Kendall Melissa M MM Rasko David A DA Sperandio Vanessa V

Infection and immunity 20070716 10

Intrakingdom cell-to-cell communication and interkingdom cell-to-cell communication play essential roles in the virulence of enterohemorrhagic Escherichia coli (EHEC). Four signals, autoinducer 2 (AI-2), AI-3, and the human hormones epinephrine and norepinephrine, are important in this communication. The effect of these signaling compounds on the transcriptome of EHEC was examined in this study. We demonstrated that the luxS mutation affects primarily central metabolic genes in both pathogenic a ...[more]

PMID: 17635870

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