Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Noa Bossel Ben-Moshe
PROVIDER: E-GEOD-74493 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Furth Noa N Bossel Ben-Moshe Noa N Pozniak Yair Y Porat Ziv Z Geiger Tamar T Domany Eytan E Aylon Yael Y Oren Moshe M
Genes & development 20151101 22
p53 is a pivotal tumor suppressor and a major barrier against cancer. We now report that silencing of the Hippo pathway tumor suppressors LATS1 and LATS2 in nontransformed mammary epithelial cells reduces p53 phosphorylation and increases its association with the p52 NF-κB subunit. Moreover, it partly shifts p53's conformation and transcriptional output toward a state resembling cancer-associated p53 mutants and endows p53 with the ability to promote cell migration. Notably, LATS1 and LATS2 are ...[more]