Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Expression data of genes from the gustatory cortex follwing novel taste learning

ABSTRACT: Novel taste memories, critical for animal survival, are consolidated to form long term memories which are dependent on translation regulation in the gustatory cortex We used microarray for identification of genes involved in novel taste learning at two time points- 1 and 3 hours following memory formation for novel taste Adult rats were separated into two groups- novel tatse (0.1% sacchain) and water, two time points were used 1, 3 hours following learnin. Rna was extracted and hybridized on Affymetrix microarray

ORGANISM(S): Rattus norvegicus

SUBMITTER: Ian Simpson

PROVIDER: E-GEOD-74546 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Fluid consumption and taste novelty determines transcription temporal dynamics in the gustatory cortex.

Inberg Sharon S Jacob Eyal E Elkobi Alina A Edry Efrat E Rappaport Akiva A Simpson T Ian TI Armstrong J Douglas JD Shomron Noam N Pasmanik-Chor Metsada M Rosenblum Kobi K

Molecular brain 20160209

<h4>Background</h4>Novel taste memories, critical for animal survival, are consolidated to form long term memories which are dependent on translation regulation in the gustatory cortex (GC) hours following acquisition. However, the role of transcription regulation in the process is unknown.<h4>Results</h4>Here, we report that transcription in the GC is necessary for taste learning in rats, and that drinking and its consequences, as well as the novel taste experience, affect transcription in the ...[more]

PMID: 26856319

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Project description:Deficits in chemosensory processing are associated with healthy aging, as well as numerous neurodegenerative disorders, including Alzheimer’s Disease (AD). In many cases, chemosensory deficits are harbingers of neurodegenerative disease, and understanding the mechanistic basis for these changes may provide insight into the fundamental dysfunction associated with aging and neurodegeneration. The fruit fly, Drosophila melanogaster, is a powerful model for studying chemosensation, aging, and aging-related pathologies, yet the effects of aging and neurodegeneration on chemosensation remain largely unexplored in this model, particularly with respect to taste. To determine whether the effects of aging on taste are conserved in flies, we compared the response of flies to different appetitive tastants. Aging impaired response to sugars, but not medium-chain fatty acids that are sensed by a shared population of neurons, revealing modality-specific deficits in taste. Selective expression of the human amyloid beta (Ab) 1-42 peptide bearing the Arctic mutation (E693E) associated with early onset AD in the neurons that sense sugars and fatty acids phenocopies the effects of aging, suggesting that the age-related decline in response is localized to gustatory neurons. Functional imaging of gustatory axon terminals revealed reduced response to sugar, but not fatty acids. Axonal innervation of the fly taste center was largely intact in aged flies, suggesting that reduced sucrose response does not derive from neurodegeneration. Conversely, expression of the amyloid peptide in sweet-sensing taste neurons resulted in reduced innervation of the primary fly taste center. A comparison of transcript expression within the sugar-sensing taste neurons revealed age-related changes in 66 genes, including a reduction in odorant-binding protein class genes that are also expressed in taste sensilla. Together, these findings suggest that deficits in taste detection may result from signaling pathway-specific changes, while different mechanisms underly taste deficits in aged and AD model flies. Overall, this work provides a model to examine cellular deficits in neural function associated with aging and AD.

Dataset Information

Expression data of genes from the gustatory cortex follwing novel taste learning

Publications

Fluid consumption and taste novelty determines transcription temporal dynamics in the gustatory cortex.

Similar Datasets

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