Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ying Sun
PROVIDER: E-GEOD-74724 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Sun Shuying S Sun Ying Y Ling Shuo-Chien SC Ferraiuolo Laura L McAlonis-Downes Melissa M Zou Yiyang Y Drenner Kevin K Wang Yin Y Ditsworth Dara D Tokunaga Seiya S Kopelevich Alex A Kaspar Brian K BK Lagier-Tourenne Clotilde C Cleveland Don W DW
Proceedings of the National Academy of Sciences of the United States of America 20151130 50
Ubiquitous expression of amyotrophic lateral sclerosis (ALS)-causing mutations in superoxide dismutase 1 (SOD1) provokes noncell autonomous paralytic disease. By combining ribosome affinity purification and high-throughput sequencing, a cascade of mutant SOD1-dependent, cell type-specific changes are now identified. Initial mutant-dependent damage is restricted to motor neurons and includes synapse and metabolic abnormalities, endoplasmic reticulum (ER) stress, and selective activation of the PR ...[more]