O-linked β-N-acetylglucosamine (O-GlcNAc) acts as a glucose sensor to epigenetically regulate the insulin gene in pancreatic beta cells
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ABSTRACT: We compare global gene expression changes in the Min6 cell line in response to altered glucose flux and pharmacological manipulation of the O-GlcNAc postranslational protein modification. Min6 cells were treated for 1hr in the following conditions: Low glucose (LG), high glucose (HG) and LG+GlcNAcstatin (LG+GNS). After treatment, total RNA was extracted and used for sequencing.
ORGANISM(S): Mus musculus
SUBMITTER: Lance Wells
PROVIDER: E-GEOD-74980 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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