RNA-sequencing analysis of gilt blood gene expression during Porcine Reproductive and Respiratory Syndrom Virus infection

ABSTRACT: Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant females causes fetal death and increased piglet mortality, but there is substantial variation in the extent of reproductive pathology between individual dams. This study used RNA-sequencing to characterize the whole blood transcriptional response to PRRSV in pregnant gilts during the first week of infection, and attempted to identify gene expression signatures associated with a low or high level of fetal mortality at necropsy, 21 days post-inoculation. RNA-sequencing experiment compared whole blood gene expression in two groups of gilts: a low fetal mortality group (LFM) and a high fetal mortality (HFM) group (n=8 per group). Two sets of contrasts were perfromed. First, a time-course experiment in which gene

ORGANISM(S): Sus scrofa

SUBMITTER: James Wilkinson 

PROVIDER: E-GEOD-75304 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress