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Transcription profiling of human samples of multiple myeloma patients with and without bone lytic lesion by MRI

ABSTRACT: This series represents samples of multiple myeloma patients with and without bone lytic lesion by MRI.

ORGANISM(S): Homo sapiens

DISEASE(S): with bone lytic lesion

SUBMITTER: John Shaughnessy

PROVIDER: E-GEOD-755 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma.

Tian Erming E Zhan Fenghuang F Walker Ronald R Rasmussen Erik E Ma Yupo Y Barlogie Bart B Shaughnessy John D JD

The New England journal of medicine 20031201 26

<h4>Background</h4>Myeloma cells may secrete factors that affect the function of osteoblasts, osteoclasts, or both.<h4>Methods</h4>We subjected purified plasma cells from the bone marrow of patients with newly diagnosed multiple myeloma and control subjects to oligonucleotide microarray profiling and biochemical and immunohistochemical analyses to identify molecular determinants of osteolytic lesions.<h4>Results</h4>We studied 45 control subjects, 36 patients with multiple myeloma in whom focal ...[more]

PMID: 14695408

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