Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jennifer Jane Westendorf
PROVIDER: E-GEOD-75552 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Carpio Lomeli R LR Bradley Elizabeth W EW McGee-Lawrence Meghan E ME Weivoda Megan M MM Poston Daniel D DD Dudakovic Amel A Xu Ming M Tchkonia Tamar T Kirkland James L JL van Wijnen Andre J AJ Oursler Merry Jo MJ Westendorf Jennifer J JJ
Science signaling 20160809 440
Histone deacetylase (HDAC) inhibitors are efficacious epigenetic-based therapies for some cancers and neurological disorders; however, each of these drugs inhibits multiple HDACs and has detrimental effects on the skeleton. To better understand how HDAC inhibitors affect endochondral bone formation, we conditionally deleted one of their targets, Hdac3, pre- and postnatally in type II collagen α1 (Col2α1)-expressing chondrocytes. Embryonic deletion was lethal, but postnatal deletion of Hdac3 dela ...[more]