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Transcription profiling of cultured human ovarian cancer cells vincristine-sensitive parental ovarian tumor cell line (SKOV3) and its highly vincristine-resistant derivative

ABSTRACT: Gene expression profiles were assessed for vincristine-sensitive parental ovarian tumor cell line (SKOV3) and its highly vincristine-resistant derivative (SKVCR 2.0) Experiment Overall Design: Duplicate gene expression microarray experiments were undertaken for each of SKOV3 and SKVCR 2.0. Comparative analysis between these two groups defined genes activated in vincristine resistance

ORGANISM(S): Homo sapiens

SUBMITTER: T Buys 

PROVIDER: E-GEOD-7556 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genetic changes in the evolution of multidrug resistance for cultured human ovarian cancer cells.

Buys Timon P H TP   Chari Raj R   Lee Eric H L EH   Zhang May M   MacAulay Calum C   Lam Stephen S   Lam Wan L WL   Ling Victor V  

Genes, chromosomes & cancer 20071201 12

The multidrug resistant (MDR) phenotype is often attributed to the activity of ATP-binding cassette (ABC) transporters such as P-glycoprotein (ABCB1). Previous work has suggested that modulation of MDR may not necessarily be a single gene trait. To identify factors that contribute to the emergence of MDR, we undertook integrative genomics analysis of the ovarian carcinoma cell line SKOV3 and a series of MDR derivatives of this line (SKVCRs). As resistance increased, comparative analysis of gene  ...[more]

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